Curriculum Vitae

Education

April 2004: Doctor of Philosophy in Physics
Dissertation Title: “Isospin Breaking and Radiative Corrections in Semileptonic Kaon Decays” (Centre de Physique Théorique, Marseille).

2000: Master’s Degree in High Energy Physics (Université de la Méditerranée, Marseille).

1997: Bachelor’s Degree in Physics (Université Pierre et Marie Curie, Paris).

Experience

December 2020 – July 2022

Member of the LITO (Laboratory of Translational Imaging in Oncology) research unit.

Segmentation of PET/CT images (LIFEx software, deep learning) and extraction of radiomic features.

Search for patients with similar radiomic and clinical characteristics (“twin patients”).

Prediction models (type of cancer and/or response to treatment).

Development of Artificial Intelligence tools for oncology (lung and breast cancer).

New prognostic biomarkers in [18F]FDG-PET images and evaluation in independent cohorts of NSCLC patients.

October 2018 – October 2020

Centre de Recherche en Cancérologie de Marseille

Member of the SMARTc (Simulation Modeling Adaptive Response for Therapeutics in Cancer) team composed of mathematicians, physicists, oncologists and pharmacists.

Development of mathematical models dedicated to the determination of optimal features (dose, protocol) when combining immune check-point inhibitors with other treatment modalities such as radiotherapy or chemotherapy.

Development of a machine learning analysis to forecast the ifosfamide induced haematological toxicities knowing the patient’s neutrophil and platelet initial values and the ifosfamide dose. Our models were able to reproduce the dynamic profiles of the haematological toxicities. Adjusting a patient’s ifosfamide dose based on the predicted haematological toxicity levels at the end of a treatment cycle could enable a tailored follow-up during the treatment.

Combining chemograms (drug sensitivity), omic data (proteomic, secretomic), machine learning techniques (chemogram-derived clustering and sensitivity assignment), statistical tests (most significant set of proteins) and multiprocessing, we have identified a set of molecular signatures that could allow to predict the clinical course and chemo-sensitivity of this disease. Currently, this set of proteins (which discriminates between sensitive and resistant patients) is part of a validation study.

August 2017 – July 2018

autobiz

Development of predictive algorithms in the field of vehicle transactions for professionals of distribution.

Application of methods such as deep learning to time series forecasting, neural network for regression problems or more sophisticated machine learning algorithms.

June 2015 – December 2016

Commissariat à l’Energie Atomique et aux Energies Alternatives

Simulation of nanoparticle-mediated hyperthermal cancer therapy

Dec 2013 – April 2015

Nuclear Medicine Service

University College London Hospital

Drug escalation study (GlaxoSmithKline) in patients with Idiopathic Pulmonary Fibrosis

Tissue fraction correction in lung PET/CT imaging

Data driven gating using Principal Component Analysis

Quantification of registered respiratory gated PET/CT images in the lung

Nov. 2011 – Mars 2013

Commissariat à l’Energie Atomique et aux Energies Alternatives

Centre National de la Recherche Scientifique

Extension of GATE (Simulation of clinical and pre-clinical scans acquired in Emission Tomography, Computed Tomography and radiotherapy treatments) to model optical imaging experiments such as bioluminescence and fluorescence

Development of a hybrid (CPU/GPU) version of the GATE optical module

May 2008 – Oct. 2010

Rice University

Based at the European Organization for Nuclear Research (CERN) (Geneva, Switzerland)

Member of the Compact Muon Solenoid (CMS) experiment

Physics analysis: Measurement of the ttbar production cross section in early 7TeV data by looking for semileptonic decays of the top quark pairs in the electron channel with reliance on simple secondary vertex b-tagging

Convener/Project Manager of the CMS Tracker Simulation group:

– Management of the group

– Responsible for the CMS pixel simulation: detector geometry and response (digitization)

– Commissioning and performance of the CMS pixel tracker with cosmic ray muons

CMS Pixel shifter (CMS control room webcams)

CMS Tracker Offline shift Leader

Apr. – May 2008

University at Buffalo

March 2008

Kansas State University

Finalizing the DO publication: Search for a scalar or vector particle decaying into Zγ in ppbar collisions at center of mass energy of 1.96 TeV

Feb. 2006 – Feb. 2008

Purdue University Calumet

Based at the Fermi National Accelerator Laboratory (Fermilab, Batavia, Illinois, USA)

Member of the Compact Muon Solenoid(CMS) experiment at CERN and the DO experiment at Fermilab

Responsible of the burn-in tests of the CMS forward pixel modules at the Fermilab Silicon Detector facility

In charge of the update/maintenance of the CMS forward pixel detector geometry and material description in the CMS simulation

Contribution to the DO missing transverse energy algorithm for the Level3 Trigger group

DO physics analysis: Search for a scalar or vector particle decaying into Zγ in ppbar collisions at center of mass energy of 1.96 TeV

Research Experience before PhD

Mar. – Jun. 2000: Master thesis (Centre de Physique Théorique, Marseille, France)

Semileptonic pion and kaon decays – radiative corrections in K_l2 decays

Jul. – Aug. 1999: Internship at Fermilab

Contribution to the development of the MuoExamine software for the online data analysis from the D0 muon chambers

Feb. – Jun. 1999: Internship at the Laboratoire de Physique Nucléaire et Hautes Energies (University Paris VI, France)

Contribution to the software used to reconstruct the missing transverse energy in the D0 experiment

Jun. – Aug. 1998: Internship at Fermilab

Assembly and test of scintillation counters for the D0 central muon detector upgrade

Jun. – Jul. 1997: Internship at Laboratoire Léon Brillouin (LLB, CEA-Saclay, France)

Study of the Betaine Calcium Chloride Dihydrate temperature phase diagram using a 2-axes spectrometer at the LLB ORPHEE neutron reactor. The BCCD is a dielectric cristal which has commensurate and incommensurate temperature phase diagrams

Responsibilities

Volunteer for The Black Fish UK (since February 2014).

Convener/Project Manager of the CMS Tracker Simulation group (2008–2010).

SAM (Sequential data Access via Meta-data) offline shifter (2006–2008) for DO experiment at Fermilab.

Teaching Assistant (2001–2003) in Functional Analysis for undergraduate students of the Institut de Mathématiques de Luminy, Marseille.

Elected as PhD representative member at the Centre de Physique Théorique Executive Council and co-organiser of the Rendez-Vous des Thésards (seminars by PhD students and post-docs) from 2000 to 2003.