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Curriculum Vitae

Education
Experience
  • Since December 2020

    Research Associate at Institut Curie – INSERM (Orsay, France).

    • Member of the LITO (Laboratory of Translational Imaging in Oncology) research unit.
    • Segmentation of PET/CT images (LIFEx software, deep learning) and extraction of radiomic features.
    • Search for patients with similar radiomic and clinical characteristics (“twin patients”).
    • Prediction models (type of cancer and/or response to treatment).
    • Development of Artificial Intelligence tools for oncology (lung and breast cancer).
    • October 2018 – October 2020

      Research Associate at Centre de Recherche en Cancérologie de Marseille (Marseille, France).

      • Member of the SMARTc (Simulation Modeling Adaptive Response for Therapeutics in Cancer) team composed of mathematicians, physicists, oncologists and pharmacists.
      • Development of mathematical models dedicated to the determination of optimal features (dose, protocol) when combining immune check-point inhibitors with other treatment modalities such as radiotherapy or chemotherapy.
      • Development of a machine learning analysis to forecast the ifosfamide induced haematological toxicities knowing the patient’s neutrophil and platelet initial values and the ifosfamide dose. Our models were able to reproduce the dynamic profiles of the haematological toxicities. Adjusting a patient’s ifosfamide dose based on the predicted haematological toxicity levels at the end of a treatment cycle could enable a tailored follow-up during the treatment.
      • Combining chemograms (drug sensitivity), omic data (proteomic, secretomic), machine learning techniques (chemogram-derived clustering and sensitivity assignment), statistical tests (most significant set of proteins) and multiprocessing, we have identified a set of molecular signatures that could allow to predict the clinical course and chemo-sensitivity of this disease. Currently, this set of proteins (which discriminates between sensitive and resistant patients) is part of a validation study.
      • August 2017 – July 2018

        Data scientist at autobiz (Suresnes, France).

        • Development of predictive algorithms in the field of vehicle transactions for professionals of distribution.
        • Application of methods such as deep learning to time series forecasting, neural network for regression problems or more sophisticated machine learning algorithms.
        • June 2015 – December 2016

          Research Associate at the Commissariat à l’Energie Atomique et aux Energies Alternatives, Service Hospitalier Frederic Joliot (Orsay, France).

          • Simulation of nanoparticle-mediated hyperthermal cancer therapy
          • Dec 2013 – April 2015

            Research Associate at the Nuclear Medicine Service of the University College London Hospital (London, United-Kingdom).

            • Drug escalation study (GlaxoSmithKline) in patients with Idiopathic Pulmonary Fibrosis
            • Tissue fraction correction in lung PET/CT imaging
            • Data driven gating using Principal Component Analysis
            • Quantification of registered respiratory gated PET/CT images in the lung
            • Nov. 2011 – Mars 2013

              Post-doctoral Researcher for the Commissariat à l’Energie Atomique et aux Energies Alternatives and the Centre National de la Recherche Scientifique, Service Hospitalier Frederic Joliot (Orsay, France)

              • Extension of GATE (Simulation of clinical and pre-clinical scans acquired in Emission Tomography, Computed Tomography and radiotherapy treatments) to model optical imaging experiments such as bioluminescence and fluorescence
              • Development of a hybrid (CPU/GPU) version of the GATE optical module
              • May 2008 – Oct. 2010

                Post-doctoral Research Associate at Rice University (Houston, Texas, USA)

                • Based at the European Organization for Nuclear Research (CERN) (Geneva, Switzerland)
                • Member of the Compact Muon Solenoid (CMS) experiment
                • Physics analysis: Measurement of the ttbar production cross section in early 7TeV data by looking for semileptonic decays of the top quark pairs in the electron channel with reliance on simple secondary vertex b-tagging
                • Convener/Project Manager of the CMS Tracker Simulation group:
                  • – Management of the group
                  • – Responsible for the CMS pixel simulation: detector geometry and response (digitization)
                  • – Commissioning and performance of the CMS pixel tracker with cosmic ray muons
                • CMS Pixel shifter (CMS control room webcams)
                • CMS Tracker Offline shift Leader
                • Apr. – May 2008

                  Post-doctoral Research Associate at the University at Buffalo (New York, USA) — Transition to Rice University.

                  • March 2008

                    Visitor Scientist at Kansas State University, Manhattan, Kansas, USA

                    • Finalizing the DO publication: Search for a scalar or vector particle decaying into Zγ in ppbar collisions at center of mass energy of 1.96 TeV
                    • Feb. 2006 – Feb. 2008

                      Post-doctoral Research Associate at Purdue University Calumet (Hammond, Indiana, USA)

                      • Based at the Fermi National Accelerator Laboratory (Fermilab, Batavia, Illinois, USA)
                      • Member of the Compact Muon Solenoid(CMS) experiment at CERN and the DO experiment at Fermilab
                      • Responsible of the burn-in tests of the CMS forward pixel modules at the Fermilab Silicon Detector facility
                      • In charge of the update/maintenance of the CMS forward pixel detector geometry and material description in the CMS simulation
                      • Contribution to the DO missing transverse energy algorithm for the Level3 Trigger group
                      • DO physics analysis: Search for a scalar or vector particle decaying into Zγ in ppbar collisions at center of mass energy of 1.96 TeV
                      Research Experience before PhD
                        Semileptonic pion and kaon decays – radiative corrections in Kl2 decays

                        • Jul. – Aug. 1999: Internship at Fermilab
                          Contribution to the development of the MuoExamine software for the online data analysis from the D0 muon chambers

                            Contribution to the software used to reconstruct the missing transverse energy in the D0 experiment

                            • Jun. – Aug. 1998: Internship at Fermilab
                              Assembly and test of scintillation counters for the D0 central muon detector upgrade

                                Study of the Betaine Calcium Chloride Dihydrate temperature phase diagram using a 2-axes spectrometer at the LLB ORPHEE neutron reactor. The BCCD is a dielectric cristal which has commensurate and incommensurate temperature phase diagrams

                                Responsibilities
                                • Volunteer for The Black Fish UK (since February 2014).
                                  • Convener/Project Manager of the CMS Tracker Simulation group (2008–2010).
                                    • SAM (Sequential data Access via Meta-data) offline shifter (2006–2008) for DO experiment at Fermilab.
                                      • Teaching Assistant (2001–2003) in Functional Analysis for undergraduate students of the Institut de Mathématiques de Luminy, Marseille.
                                        • Elected as PhD representative member at the Centre de Physique Théorique Executive Council and co-organiser of the Rendez-Vous des Thésards (seminars by PhD students and post-docs) from 2000 to 2003.
                                          • Part-time Secretary of Professor René Turlay, General-Secretary of the International Union of Pure and Applied Physics (1998–2002).
                                          • Languages
                                              French (mother tongue)
                                              English (fluent)
                                              Bosnian/Croatian/Serbian (fluent)

                                              Computing
                                                Operating systems: Linux, Mac OS and Windows.

                                                  Programming languages: C++, Python, bash scripting, GPU programming (Cuda), MATLAB

                                                    Markup languages: XML, HTML.

                                                      Softwares & Frameworks: Mathematica (computational software program), ROOT (data analysis object oriented framework), Geant4 (simulation of the passage of particles through matter), IGUANA (CERN C++ toolkit for graphical user interfaces, interactive detector and event visualisation), Anatomist, Imagej, Slicer 3D, amide, ITK (Insight Segmentation and Registration Toolkit), Apache Spark(cluster-computing framework)

                                                        Other: LaTeX, WordPress, Word, Powerpoint, Excel.

                                                        Hobbies and Interests
                                                          Yoga, Hiking, Jogging
                                                          Tortoise
                                                          History of France (particularly the XVII and XVIIIth centuries)